VOILA Study
Networks
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Datasets
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Variables
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DuSRA-VOILA is the largest collaboration in the field of ageing research in the Netherlands. As of October 2019, nine institutions and eight private partners participate in a comprehensive 5-year research programme of solutions which can contribute to ageing healthily as well as improving personal vitality. DuSRA stands for Dutch Society for Research on Ageing, VOILA stands for Vitality Oriented Innovations for the Lifecourse of the Ageing Society. The programme is co-financed by a grant of 6 million euros from The Netherlands Organisation for Health Research and Development (ZonMw) and Health~Holland, Top Sector Life Sciences & Health. Another 2.5 million euros is contributed by private partners.
A wide-ranging and multi-disciplinary team of experts of research into ageing will work together on solutions that contribute to healthy ageing and increased vitality. The team aims to attenuate functional decline in seniors to allow them to increase the number of healthy years. The life expectancy of the Dutch keeps increasing, but with this longer life comes the risk of diseases of old age. Diseases that can often be delayed or even prevented by making life style changes in nutrition, physical activity, sleep and stress. Unfortunately, general life style interventions do not work equally well for everyone. There is much diversity in older adults in their health and frailty, and so far only limited research is available into individual functional decline. In DuSRA-VOILA, we have created a unique platform for structural, multi-disciplinary cooperation in the area of ageing with vitality, aiming to identify combinations of biomarkers of early signs of functional decline in seniors, attenuate decline and restore body functions at the organismal and cellular level to allow seniors to increase the number of healthy years.
- Start Year
- 2022
- End Year
- 2025
Design
- Study design
- Clinical trial
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 144
- Number of participants with biosamples
- 144
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |
Timeline
Populations
REF (Reference Group); Community-dwelling healthy older adults with good metabolic health and mobility and who are physically active; reference population for comparison with compromised groups. This population was assessed at the Leiden University Medical Center in Leiden, the Netherlands.
Selection Criteria
- Minimum age
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62
- Maximum age
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87
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Leiden
- Ethnic Origin
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- Health Status
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- Metabolically healthy older adults
- Other criteria
- Meet Dutch physical activity guidelines (≥30 minutes moderate activity ≥5 days/week); MetaboHealth score (https://doi.org/10.1038/s41467-019-11311-9) below metabolic compromise threshold of (mean) 0.
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
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- Specific population
- Participants from existing studies
- Specific Population
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- Other specific population : Additional recruited through advertisements
- Participants from existing studies
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- Leiden Longevity Study (LLS) cohort (https://leidenlangleven.nl/)
Number of participants
- Number of participants
- 37
- Number of participants with biosamples
- 37
Data Collection Events
MetC (Metabolically compromised - intervention): Community-dwelling older adults with impaired metabolic health. This population was assessed at the Leiden University Medical Center in Leiden, the Netherlands.
Selection Criteria
- Minimum age
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60
- Maximum age
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86
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Leiden
- Ethnic Origin
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- Health Status
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- Metabolic health impairment
- Other criteria
- MetaboHealth score (https://doi.org/10.1038/s41467-019-11311-9) in top half of participants aged ≥60 years.
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Other specific population : Recruitment through advertisements
Number of participants
- Number of participants
- 33
- Number of participants with biosamples
- 33
Data Collection Events
MobC (Mobility compromised - intervention): Community-dwelling older adults with impaired mobility or reduced lower-body function. This population was assesed at Wageningen University & Research in the Netherlands.
Selection Criteria
- Minimum age
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60
- Maximum age
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91
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Wageningen
- Ethnic Origin
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- Health Status
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- Mobility limitations
- Other criteria
- Able to walk but requiring walking aids outside the home; and/or five-times chair stand test ≥15 second.
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Other specific population : Older adults with mobility limitations
Number of participants
- Number of participants
- 38
- Number of participants with biosamples
- 38
Data Collection Events
TKR-S (Knee replacement - standard care): Patients recovering from elective knee replacement receiving standard postoperative care. This population was assessed at the Maastricht University Medical Center in the Netherlands.
Selection Criteria
- Minimum age
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60
- Maximum age
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81
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Maastricht
- Ethnic Origin
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- Health Status
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- Postoperative knee primary osteoarthritis patients
- Other criteria
- Total knee replacement surgery; baseline testing approximetaly 6 weeks after surgery and receiving standard care.
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
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- Specific population
- Specific Population
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- Clinic patients
Number of participants
- Number of participants
- 15
- Number of participants with biosamples
- 15
Data Collection Events
TKRV (Knee replacement - VOILA - intervention): Patients recovering from elective knee replacement participating in the VOILA intervention programme. This population was assessed at the Maastricht University Medical Center in the Netherlands.
Selection Criteria
- Minimum age
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62
- Maximum age
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81
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Maastricht
- Ethnic Origin
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- Health Status
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- Postoperative knee osteoarthritis patients
- Other criteria
- Total knee replacement surgery; baseline testing approximately 6 weeks after surgery; participation in VOILA intervention.
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
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- Clinic patients
Number of participants
- Number of participants
- 21
- Number of participants with biosamples
- 21
Data Collection Events
Metabolically compromised - dropouts: Community-dwelling older adults with impaired metabolic health who dropped out of the study.
Selection Criteria
- Minimum age
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60
- Maximum age
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86
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Leiden
- Ethnic Origin
-
- Health Status
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- Metabolic health impairment
- Other criteria
- MetaboHealth score (https://doi.org/10.1038/s41467-019-11311-9) in top half of participants aged ≥60 years.
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Recruitment through advertisements
Number of participants
- Number of participants
- 3
- Number of participants with biosamples
- 3
Data Collection Events
Mobility compromised - dropouts: Community-dwelling older adults with impaired mobility or reduced lower-body function who dropped out of the study
Selection Criteria
- Minimum age
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64
- Maximum age
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91
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Wageningen
- Ethnic Origin
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- Health Status
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- Mobility limitations
- Other criteria
- Able to walk but requiring walking aids outside the home; and/or five-times chair stand test ≥15 second
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
-
- Other specific population : Older adults with mobility limitations
Number of participants
- Number of participants
- 3
- Number of participants with biosamples
- 3
Data Collection Events
Knee replacement - VOILA - dropouts: Patients recovering from elective knee replacement participating in the VOILA intervention programme who dropped out of the study.
Selection Criteria
- Minimum age
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68
- Maximum age
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77
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- Maastricht
- Ethnic Origin
-
- Health Status
-
- Postoperative knee osteoarthritis patients
- Other criteria
- Total knee replacement surgery; baseline testing approximately 6 weeks after surgery; participation in VOILA intervention
- Supplementary Information
- Community-dwelling; BMI 18.5-35 kg/m2; MMSE ≥24; able to provide written informed consent
Recruitment
- Sources of recruitment
-
- Specific population
- Specific Population
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- Clinic patients
- Supplementary Information
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Patient undergoing knee replacement surgery
Number of participants
- Number of participants
- 4
- Number of participants with biosamples
- 4